Message from the PI:
It may sound pretty simple: stress is not good for your heart! Chronic heart failure (CHF) affects 1 in 5 individuals during their lifetime, and the occurrence of HF is rising because of the rapidly ageing global population. Despite advances in the control of cardiovascular diseases such as coronary heart disease and myocardial infarction, the incidence and prevalence of CHF continue to increase. Its high rates of morbidity and mortality impose enormous human, social and economic cost. We know many chronic human diseases, including heart failure and metabolic diseases are triggered by pathological stressors, ranging from mechanical, chemical to humoral stimulations. Yet, clinical manifestation and therapeutic response are extremely heterogeneous among heart failure patients, possibly contributed by diverse genetic background and external stressors.
The overarching mission of the lab is to reveal the genetic and genomic basis of cardiac pathologies, and to discovery novel molecular and cellular mechanisms underlying the stress response in heart. The insights learnt from stress-signaling regulation will lead to more mechanistic driven diagnosis and disease differentiation, and new effective therapies tailored to individuals. Such knowledge can be applicable to other human diseases such as obesity and diabetes. More specifically, our lab aims to 1). Discover novel components in stress signal transduction networks through systems genetic approach; 2). Establish functional and molecular mechanisms mediating stress signaling pathways; 3). Translating mechanistic insights into novel therapies in disease models of heart failure and metabolic disorders.
The laboratory is equipped with the state-of-the-art infrastructure in a newly renovated research laboratory space and supported by outstanding UCLA Core facilities. As a member of the world-renowned UCLA Cardiovascular Research Laboratories (CVRL, http://heartlab.mednet.ucla.edu/), UCLA Molecular Biology Institute (http://www.mbi.ucla.edu/), and UCLA Nano-Science Center (http://www.cnsi.ucla.edu/), we offer great opportunities to conduct multi-disciplinary research in collaboration with leaders in the field of cardiovascular physiology, molecular genetics, proteomics, genomics and systems biology. Our research program also offers comprehensive training for pre- and post-doctoral fellows interested in genomics, proteomics, molecular signaling, cell biology and pathophysiology. Our laboratory has an outstanding track record of successful trainees, and majority of our pre-doc and post-doc fellows were awarded extramural fellowships from American Heart Association and NIH through competitive review process.
Yibin Wang, Ph.D.
Chair, UCLA Cardiovascular Research
Initiative Director, Division of Molecular Medicine
Vice Chair for Research of Anesthesiology
Professor of Anesthesiology, Physiology and Medicine
- July 2014
- Dec 2013
Chen finished her thesis defense. Congratulations!
- Oct 2013
- Sep 2013
Josh Lee joined Wang lab as a graduate student in Molecular Biology Interdepartmental program. Welcome!
- Aug 2013
Dr. Christoph Rau joined Wang lab as a new postdoctoral fellow. Welcome!
- Jul 2013
Ms. Gao receives Dissertation Year Fellowship in year 2013-2014. This award consists of a $20,000 stipend, tuition and fees and a $500 research allowance to acknowledges her outstanding contribution to UCLA’s intellectual community through academic achievements.
- May 2013
Ms. Gao receives an Eli & Edythe Broad Center (BSCRC) Pre-Doctoral Fellowship in Stem Cell Science in year 2013-2014. This fellowship will provide one year support of $ 25,000 towards her stipend. Ms. Gao has receives this fellowship in 2012-2013 academic year before.
- May 2013
Mr. O'Hearn receives UCLA Vascular pre-doctoral training grant for 2013-2014. Mr. O'Hearn is Ph.D graduate student affiliated with Molecular, Cellular, Integrative Physiology Program. The traning grant will provide $22,032 towards his stipend. Congratulations!
Contact informationDepartment of Anesthesiology
University of California, Los Angeles
Division of Molecular Medicine
BH-569 CHS, Box 957115
Los Angeles, CA 90095-7115
Phone: 310 206 5197
Fax: 310 206 5907