Message from the PI:
It may sound pretty simple: stress is not good for your heart! We know many chronic human diseases, including heart failure, are caused by pathological stressors, ranging from mechanical, chemical to humoral stimulations. Yet, it is a major challenge to understand fully the signaling networks mediating physiological and pathological stress responses and to harness them for better treatment of human diseases. Chronic heart failure (CHF) affects 1 in 5 individuals during their lifetime, and the occurrence of HF is rising because of the rapidly ageing global population. Despite advances in the control of cardiovascular diseases such as coronary heart disease and myocardial infarction, the incidence and prevalence of CHF continue to increase. Its high rates of morbidity and mortality impose enormous human, social and economic costs. In the past quarter century, much progress has been made in the understanding of molecular and cellular processes that contribute to heart failure. However, major challenges remain, as the onset and progression of CHF are very heterogeneous and the current standard therapies are not effective for a significant portion of the patient population. Heart muscle cells possess intricate and robust stress-induced signal transduction networks to mediate physiological and pathological changes in stressed myocardium. Understanding the stress signal transduction in heart muscle cells would have major implications in both basic biology as well as potential novel therapies.
Our laboratory has been focusing on understanding the intracellular signaling networks involved in stress-response in mammalian cells, and translating that knowledge into potential therapies. Our research projects are centered on three related areas of investigations: 1). Discovering novel components in stress signal transduction networks; 2). Establishing functional and molecular links among signaling pathways; 3). Translating mechanistic insights into novel therapies in disease models of heart failure. The laboratory is equipped with the state-of-the-art infrastructure in a newly renovated research laboratory space and supported by outstanding UCLA Core facilities. As a member of the world-renowned UCLA Cardiovascular Research Laboratories (CVRL, http://heartlab.mednet.ucla.edu/), UCLA Molecular Biology Institute (http://www.mbi.ucla.edu/), and UCLA Nano-Science Center (http://www.cnsi.ucla.edu/), we offer great opportunities to conduct multi-disciplinary research in collaboration with leaders in the field of cardiovascular physiology, molecular genetics, proteomics, genomics and systems biology.
Our research program also offers comprehensive training for pre- and post-doctoral fellows interested in genomics, proteomics, molecular signaling, cell biology and pathophysiology. Our laboratory has an outstanding track record of successful trainees, and majority of our pre-doc and post-doc fellows were awarded extramural fellowships from American Heart Association and NIH through competitive review process as listed in the Awards section. If you are a highly motivated individual with desire to succeed, to learn and to make a major impact on science and human health, please join our team! Together, we can make a difference!
Yibin Wang, Ph.D.
Professor of Anesthesiology, Physiology and Medicine
Director of the Division of Molecular Medicine
- May 2013
Ms. Gao receives an Eli & Edythe Broad Center (BSCRC) Pre-Doctoral Fellowship in Stem Cell Science in year 2013-2014. This fellowship will provide one year support of $ 25,000 towards her stipend. Ms. Gao has receives this fellowship in 2012-2013 academic year before.
- May 2013
Mr. O'Hearn receives UCLA Vascular pre-doctoral training grant for 2013-2014. Mr. O'Hearn is Ph.D graduate student affiliated with Molecular, Cellular, Integrative Physiology Program. The traning grant will provide $22,032 towards his stipend. Congratulations!
- June 2012
Ms. Gao Receives an Eli & Edythe Broad Center (BSCRC) Pre-Doctoral Fellowship In Stem Cell Science, congratulations!
Ms. Chen Gao, a Ph.D. graduate student affiliated with Molecular Biology Interdepartmental Program (MBIDP) has been awarded an Eli & Edythe Broad Center at UCLA (BSCRC) Pre-Doctoral Fellowship In Stem Cell Science. Ms. Gao is investigating transcriptome maturation in cardiac development and diseases by focusing on the regulatory mechanisms of mRNA splicing. This fellowship will provide one year support of $29,000 towards her stipend. Ms. Gao completed her undergraduate study in Nankai University, China and joined UCLA MBIDP Ph.D. program in 2009. She is currently conducting thesis research in the Division of Molecular Medicine at Department of Anesthesiology under the supervision of Dr. Yibin Wang.
Contact informationDepartment of Anesthesiology
University of California, Los Angeles
Division of Molecular Medicine
BH-569 CHS, Box 957115
Los Angeles, CA 90095-7115
Phone: 310 206 5197
Fax: 310 206 5907