Antonios Pantazis, PhD, has been awarded a prestigious Scientist Development Grant by the American Heart Association National Center Research Program. The title of the award is "The Molecular Basis of Beta Subunit Modulation of the Human BK Channel Voltage Dependence". In this project, Dr. Pantazis will use state-of-the-art optical and electrophysiological techniques and computational modeling to elucidate the structural basis and physically-relevant mechanism of BK channel modulation by tissue-specific beta subunits: an important molecular interaction occuring in most cells of the body which is critical for the regulation of blood pressure and could guide future therapeutic strategies for hypertension and stroke. The Scientist Development Grant mechanism provides a total of $308,000 for four years and is designed to promote the independent status of outstanding new investigators.
Dr. Pantazis received his PhD from Cambridge University in 2006. He joined the laboratory of Dr. Riccardo Olcese in the Division of Molecular Medicine, Dept. of Anesthesiology, UCLA David Geffen School of Medicine in 2008 as a postdoctoral scholar and was promoted to his first faculty position in 2012. He has been receiving uninterrupted support from competitive American Heart Association fellowships and grants since 2009, including two Postdoctoral Fellowships, a Beginning Grant-in-Aid and the Scientist Development Grant.